The Solo Adventures screen is where players access various single-player game modes, consisting of Practice mode, Adventures, and Missions. The screen can be accessed through the Solo Adventures button from the main menu.
- Main article: Mission
Selecting a mission will take the player into the screen for that content.
- Lich King missions — August 10, 2017 — Knights of the Frozen Throne — Free
- Dungeon Run — December 7, 2017 — Kobolds & Catacombs — Free
- Monster Hunt — April 26, 2018 — The Witchwood — Free
- Puzzle Lab — August 21, 2018 — The Boomsday Project — Free
- Rumble Run — December 13, 2018 — Rastakhan's Rumble — Free
- The Dalaran Heist — May 16, 2019 — Rise of Shadows
- Tombs of Terror — September 17, 2019 — Saviors of Uldum
- Demon Hunter Prologue — April 2, 2020 — Ashes of Outland — Free
- Trial by Felfire — June 17, 2020 — Ashes of Outland — Free
- Book of Heroes — September 15, 2020 — Scholomance Academy (First release) — Free
- Book of Mercenaries — April 6, 2021 — Forged in the Barrens (First release) — Free
- Main article: Adventure
Selecting an adventure will take the player into the screen for that adventure. There are a total of five Adventures: Template:List of Adventures
- Main article: Practice mode
Practice mode is a type of game mode in which the player does battle against the computer in practice sparring matches. Players select either Basic or Expert difficulty, and then a class for the opponent to play as. The opponent's decks are all predetermined, as listed in Practice mode#Decks.
Practice mode is the ideal mode for learning the basics of the game, exploring new classes, leveling or unlocking heroes, and trying out new strategies. Practice mode matches are played against The Innkeeper.
- Patch 188.8.131.52662 (2021-03-25): Fixed a bug where clicking the victory banner in Solo Adventures would not exit the match.
- Patch 184.108.40.20624 (2014-07-22):
- The Solo Adventures screen has been added, and can be accessed from the main menu through the Solo Adventures button, replacing the Practice button. The Practice mode screen is now entered through the Solo Adventures screen.